Pharmacogenetics Testing

Pharmacogenetics (PGx) is the study of how a person’s genetic make-up influences their response to particular medications. Results of PGx testing may help optimize medication choice and dosage, which could improve efficacy and could reduce adverse effects more quickly than the typical “trial and error” approach.

Lineagen’s pharmacogenetics (PGx) test analyzes 73 variants on 15 genes. PGx testing is one aspect of personalized medicine and is used to aid health care providers with prescribing medications and dosage.

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Pharmacogenetic (PGx) testing looks at common variants within genes known to play a role in medication metabolism (the breakdown of medications). The results of this test may help your doctor determine medication dosage and choice. This may help improve your response to the medication and may reduce the risk for side effects.
Though a person's particular combination of genetic variants may impact their response to medications, PGx testing is considered just one piece to a person's unique puzzle. Many other genetic and non-genetic factors (some of which are currently unknown) also likely play a role in medication metabolism and response. It is very important to discuss your PGx results with your healthcare providers before any changes to medication treatment plans are made.
PGx testing looks at common genetic variants within specific genes known to play a role in medication metabolism (or the breakdown of medications). CMA looks at all of the genetic material in a person's chromosomes (packages of DNA) to find rare genetic variants, such as missing or extra pieces. In this way, CMA can pinpoint a genetic diagnosis, or cause, for a person's symptoms.
PGx testing can be performed using a cheek swab. If other tests are ordered, such as Lineagen’s FirstStepDx PLUS CMA, NextStepDx PLUS WES, or fragile X syndrome testing, PGx can be performed on the same cheek swab sample. Learn how to order here.

Results will be available in about 3-4 weeks. Of note, PGx test results are sent directly to the ordering physician, who will contact you to review.